Abstract

Laxman D Bulbule39652*, RK Godge39653 and Sagar Magar39654

Hydralazine is antihypertensive agent which is smooth muscle relaxant helps to treat high blood pressure. Hydralazine comes in a class of medications called vasodilators. It works by relaxing the blood vessels so that blood can flow more easily through the body. Isosorbide Dinitrate is antianginal agent which is used to prevent chest pain in patients with a certain heart condition (coronary artery disease). This medication belongs to a class of drugs known as nitrates. It works by relaxing and widening blood vessels so blood can flow more easily to the heart. This is the literature review of developed various analytical method for validation and estimation of Hydralazine, Isosorbide Dinitrate in combination. The analytical method like RP-HPLC (Revere Phase High Performance Liquid Chromatography), quality by design, Ultraviolet (UV) Spectrophotometry, Simultaneous Equation Method (SEM), stability indicating method were reported for Hydralazine Hydrochloride, Isosorbide Dinitrate. These analytical methods can be used for qualitative and quantitative estimation of Isosorbide Dinitrate and Hydralazine Hydrochloride in single dosage form as well as in combination with other drugs.