Marshall Syndrome in Adults, Myth or Reality

Abstract

Karapetyan LS*, Svistushkin VM, Starostina SV, Svistushkin MV, Grigoryan IZ, Sinkov EV, Sobolev VP, Shadyev TK

Marshall syndrome or PFAPA syndrome, is a rare autoimmune disorder that is mainly found in preschool-aged children. However, medical observations show that a similar clinical picture can develop in adults, more often at the age of 20-50 years. The authors report the case series of adult patients admitted to the clinic of Ear, Throat and Nose (ENT) diseases of the PMGMU named after IM Sechenov. The particular significance of this study lies in the increasing the awareness of otolaryngologists and therapists about the Marshall’s syndrome to improve the quality of its diagnosis and treatment. There are only isolated clinical cases of adult patients with Marshall syndrome in the literature. However, despite the rare occurrence of this pathology and the difficulties in diagnosis, it is necessary to increase awareness among both healthcare professionals and patients about this clinical syndrome in order to improve the quality of its diagnosis and treatment.