Mechanisms and pharmaceutical application of solid lipid Nanoparticles as efficient drug delivery system

Abstract

Ashish B Wadekar*, Jagdish V Manwar, Ravindra L Bakal, Dipak D Kumbhar

A solid lipid nanoparticle provides the opportunity of developing new therapies due to their unique size-dependent characteristics. They are a small particle that ranges between 1-100 nm in size. Lipid nanoparticles have risen in popularity in this context due to their widespread acceptance as nontoxic, biocompatible, and simplified formulation. They are safe, efficacious, and scalable enough to be made on a large scale and advanced to clinical usage. Pharmaceutical uses of lipid nanocarriers include the transport and distribution of a wide range of therapeutic agents, from biotechnological products to tiny drug molecules. This review begins with a brief summary of the common starting materials used to make Solid Lipid Nanoparticles (SLNs), as well as their screening, SLNs formulation principles, and various methods used to formulate SLNs along with its diverse applications.

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