Notch Pathway and its Role in Cardiovascular System: Review
Abstract
Amira M. Badr, Yasmen F. Mahran
The Notch signaling pathway is a core signal transduction mechanism that control diverse cellular processes. Its activity is mandatory for normal embryonic development, as it control the transcription of genes implicated in cellular proliferation, differentiation, migration, and apoptosis. It is considered as a key regulator of neonatal cardiomyocyte development; thus, its abnormality is strongly correlated to cardiovascular congenital malformations. Despite, Notch pathway is considered relatively absent in adult heart; recent studies included evidence of the upregulation of Notch signaling pathway in response to some cardiac insults. In our review, we briefly discuss the possible role of Notch Pathway in adult cardiomyocytes and other cells involved in the cardiovascular health, and its possible contribution to cardiovascular diseases.
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| Pubmed Style Badr AM, Mahran YF. Notch Pathway and its Role in Cardiovascular System: Review. SRP. 2020; 11(10): 342-349. doi:10.31838/srp.2020.10.56 Web Style Badr AM, Mahran YF. Notch Pathway and its Role in Cardiovascular System: Review. http://www.sysrevpharm.org/?mno=27474 [Access: March 29, 2021]. doi:10.31838/srp.2020.10.56 AMA (American Medical Association) Style Badr AM, Mahran YF. Notch Pathway and its Role in Cardiovascular System: Review. SRP. 2020; 11(10): 342-349. doi:10.31838/srp.2020.10.56 Vancouver/ICMJE Style Badr AM, Mahran YF. Notch Pathway and its Role in Cardiovascular System: Review. SRP. (2020), [cited March 29, 2021]; 11(10): 342-349. doi:10.31838/srp.2020.10.56 Harvard Style Badr, A. M. & Mahran, . Y. F. (2020) Notch Pathway and its Role in Cardiovascular System: Review. SRP, 11 (10), 342-349. doi:10.31838/srp.2020.10.56 Turabian Style Badr, Amira M., and Yasmen F. Mahran. 2020. Notch Pathway and its Role in Cardiovascular System: Review. Systematic Reviews in Pharmacy, 11 (10), 342-349. doi:10.31838/srp.2020.10.56 Chicago Style Badr, Amira M., and Yasmen F. Mahran. "Notch Pathway and its Role in Cardiovascular System: Review." Systematic Reviews in Pharmacy 11 (2020), 342-349. doi:10.31838/srp.2020.10.56 MLA (The Modern Language Association) Style Badr, Amira M., and Yasmen F. Mahran. "Notch Pathway and its Role in Cardiovascular System: Review." Systematic Reviews in Pharmacy 11.10 (2020), 342-349. Print. doi:10.31838/srp.2020.10.56 APA (American Psychological Association) Style Badr, A. M. & Mahran, . Y. F. (2020) Notch Pathway and its Role in Cardiovascular System: Review. Systematic Reviews in Pharmacy, 11 (10), 342-349. doi:10.31838/srp.2020.10.56 |
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