Supersaturated Drug Delivery System: A Novel Technique to Overcome Lacunas of Topical Formulation

Abstract

Dipika Chavda40407*, Sagar Chavda40409, Jaina Patel40410, Pratik Chauhan40411 and Tejal Gandhi40412

Presently, topical preparations have grabbed researchers' attention and proved to be the safest and most patient compliant drug delivery systems. Still, some gaps must be filled to get higher penetration and effectiveness of topical drug delivery systems. The present review focuses on one such approach, which has been proven as a promising tool to enhance the solubility of BCS class II drugs and improve drug permeation rate through the skin. The formulation contains the drug with higher energy and rapid dissolution in a solvent. The solution must have to be stabilized for complete absorption and bioavailability. Therefore, supersaturated solutions are prepared by adding precipitation inhibitors to prevent crystal growth. The solubilizing agents are used to incorporate higher drug amounts in a supersaturated state. This system provides  the  highest  permeation  rate of the drug as compared to other systems in topical preparations. This article will help the researchers effectively use the supersaturated drug delivery system for newer classes of drugs to incorporate into topical preparations.