AB Harale

Department of Pharmaceutical Chemistry, Pes’s Modern College of Pharmacy, Pune, India


  • Review Article   
    Novel Nitric Oxide-Donating Pyrazoline-Coumarin as a Cyclooxygenase-2 Inhibitors for Anti-Inflammatory Activity
    Author(s): AB Harale36651*, SY Chaudhari36652 and SN Baviskar36653

    A variety of novel phenyl-pyrazoline-coumarin compounds were developed and synthesized to produce new anti-inflammatory medicines with improved pharmacological characteristics. All of the substances were tested for anti-inflammatory efficacy by measuring how well they inhibited LPS-induced Interleukin (IL)-6 productions. Compound 4m had the best anti-inflammatory action, decreasing IL-6, Tumor Necrosis Factor (TNF), and nitric oxide (NO) synthesis when induced by Li-popolysaccharide (LPS). Thr -kB ough the Nuclear Factor (NF-kB)/Mitogen-Activated Protein Kinase (MAPK) signaling pathway, title chemical 4m was found to dramatically decrease the expression of Nitric Oxide Synthase (iNOS), cox-2 (COX-2) and the production of IL-6, TNF-a , and NO. Carrageenan-induced paw edema was used to test compound 4m's anti-inflammatory efficacy the development of novel COX-2 inhibitors with high .. Read More»
    DOI: 10.31858/0975-8453.13.4.251-255

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