Ayşe Tansu Koparal
Department of Obstetrics and Gynecology, Eski?ehir Osmangazi University, Eskisehir, TurkeyPublications
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Research Article
Effects of All-Trans-Retinoic Acid on Over Cancer Culture (Ovcar-3) Alone and Combined with Classical Chemotherapeutics
Author(s): Hulusi Goktug Gurer27350, Ceren Yildiz Eren27351*, Ozlem Ozgür Gursoy27352, Ayşe Tansu Koparal27353 and Sabit Sinan Ozalp27354
Background: Ovarian cancer is the most common cause of gynecological cancer deaths; it has a very important place in gynecological oncology. Combination therapy is a treatment method that combines more than one agent used in treatment. Today it is one of the most important weapons in cancer treatment. In this study, the aim was to examine the sole and combined effects of classical CT drugs and ATRA on Ovcar-3 cells in vitro. Methods: To determine the effects of carboplatin, paclitaxel, and ATRA on Ovcar-3 cells, MTT, DAPI staining, caspase-3 and real-time PCR analyses was performed. Results: It was observed that the combination of paclitaxel+carboplatin+ATRA significantly decreased cell viability at all doses on all days. DAPI staining showed apoptosis. In apoptotic cells, it was observed that .. Read More»