Chinakorn Sujimogkol
Department of Biostatistics, University of Michigan, Michigan, USAPublications
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Research Article
Metformin Associated Lactic Acidosis in Acute Kidney Injury Patients: A Propensity Score Analysis
Author(s): Pattarapon Wongput36659* and Chinakorn Sujimogkol36660
Background: Typically, Metformin-Associated Lactic Acidosis (MALA) results in Acute Kidney Injury (AKI). It has been proposed to be treated with dialysis to remove metformin. Due to the wide range of doses used, there is little information about initiating Hemodialysis (HD) with AKI and Metformin at any given dose. Objective: To determine the relationship between risk prediction for dialysis and metformin exposure concentrations affecting AKI in hospitalized patients by comparing them to a propensity score-matched group of patients. Methods: All type 2 diabetes patients with wide anion gap metabolic acidosis, lactic acidosis or Acute Kidney Injury were reviewed. Patients were divided into two groups based on the amount of metformin they received. Propensity Score Matching (PSM) was chosen as the predictive model fo.. Read More»
DOI: 10.31858/0975-8453.13.4.256-260