Hao Liu

Department of Stromatology, Chongqing Medical University, Chongqing, China


  • Research Article   
    Identification of the Key miRNAs and Target Genes in Basal Cell Carcinoma by Bioinformatics Analysis
    Author(s): Hao Liu41475*

    The highly tissue-destructive and localized accumulation of Basal Cell Carcinoma (BCC) makes it one of the most important cancers affecting people’s lives. Existing therapeutic approaches, including surgical treatment, chemotherapy, and Hedgehog pathway inhibitors, have failed to achieve broad therapeutic effects for various reasons. This study aims to explore additional potential therapeutic targets and possible diagnostic and prognostic biomarkers using bioinformatics analysis. The Gene Expression Omnibus (GEO) database identified the microarray dataset GSE34535. The GEO2R tool was used to screen out Differentially Expressed Genes (DEGs) between BCC and non-lesional skin. Potential target genes of DE-miRNA were screened using the miRWalk, mirDIP and miRTarBase databases. Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for target g.. Read More»
    DOI: 10.31858/0975-8453.13.4.443-450

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