Qiyu Bian

Department of Infection Biology, Manchester University, Manchester, United Kingdom


  • Research Article   
    Tryptophan Hydroxylase 2 and Tryptophan Mediate Depression by Regulating Serotonin Levels
    Author(s): Qiyu Bian51862* and Jiamei Wang51863

    Depression is a neurological disorder that can affect any individual and manifests symptoms like prolonged periods of low moods and loss of appetite. The high incidence and suicide rates of depression pose a threat to daily life and social development. Researchers have identified the defective synthesis of serotonin (5-HT) as a critical risk factor for depression. Extant literature revealed several mechanisms affecting 5-HT levels, of which the Tryptophan Hydroxylase 2 ( TPH2 ) isozyme and tryptophan pathways are closely linked to depressive-like behaviors. In previous studies, patients taking the current antidepressants that target the serotonergic system experience many side effects and have high relapse rates after medicine withdrawal, suggesting that the current knowledge of the serotonergic system is insufficient. Mutations on.. Read More»
    DOI: 10.31858/0975-8453.14.1.52-57

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