Uriel Bachrach
Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, IsraelPublications
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Research Article
Author(s): Uriel Bachrach64596*
The naturally occurring polyamine-spermine can be oxidised by serum amine oxidase to yield imino-dialdehydes. Similar dialdehydes can be synthesized chemically by treating diamines with chloro-propionaldehydes. The oxidation products are cytotoxic and inhibit the growth of cancer cells as well as human, animal and plant viruses. A synthetic imino-dialdehyde, containing a diamine-hexane moiety, was more active than the spermine oxidation product and inhibited the growth of influenza and Newcastle disease viruses. The positively charged imino-dialdehydes, cross cellular membranes, interact with cellular nucleic acids and form a biologically inactive complex. Viral vaccines are usually prepared by treating viruses with formalin, which interact with viral membrane proteins. Human and or animal viruses treated with imino-dialdehydes, retain viral membranes and are therefore potent immunoge.. Read More»
DOI: 10.31858/0975-8453.14.12.742-746