Venkadeswaran Karuppasamy
Department of Biotechnology, PSR Engineering College, Tamil Nadu, IndiaPublications
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Research
The Anti-Integrity Activity of Eugenol on Inflammatory Markers of Chronic Atherosclerosis
Author(s): Venkadeswaran Karuppasamy38245*, Subramanian Kandhasamy38246, Rajeswari Ramasamy38247, Suresh Kumar Sekar38248, Venkatesh Srinivasan38249, Varalakshmi Varatharajan38250, Suganya Ramar38251, Subashini R38252 and Shalini Kannan38253
The putative anti-atherogenic, anti-oxidative, and anti-inflammatory potential of atherogenic diet-fed, eugenol-treated Wistar rats were studied. The levels of hematological parameters (Erythrocyte Sedimentation Rate (ESR), White Blood Cell (WBC), and platelet count), the mean levels of nitric oxide (NO), and C-Reactive Protein (CRP) were investigated in serum samples. The mean ESR, platelet, and total WBC counts were all significantly higher in atherogenic diet-fed (Group II) rat when compared with normal (Group I), whereas the mean ESR, platelet, and total WBC counts were significantly lower in atherogenic diet-fed followed by eugenol treatment (Group III). The mean hepatic tissue mRNA transcript level of the gene responsible for CRP, induced Nitric Oxide Synthase (iNOS), Tumour Necrosis Factor alpha (TNF-α), Interleukin (IL)-1β, and Nuclear Factor Kappa B (NF-κB) a.. Read More»
DOI: 10.31858/0975-8453.13.3.177-187