Gaikwad Sakshi

Department of Quality Assurance, Shri DD Vispute College of Pharmacy and Research Centre, Raigad, India


  • Research Article   
    Use of Polymers Showing Synergistic Effect to Increase the Release of Tolmetin Sodium in Topical Gel
    Author(s): Gaikwad Sakshi49071*, Patil Mukesh49072, Bhosale Siddhi49073, Naiknaware Tushar49074 and Jain Ashish49075

    Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the most widely prescribed drugs worldwide. They act as analgesic, anti-pyrectic and anti-inflammatory agents. This class of drug reduces pain, inflammation, lower down body temperature. They act by slowing the formation of prostaglandins and also blocks cyclooxygenase enzyme. This reduces inflammation. The major drawback is considered to be its gastrointestinal ulcers and bleeding, heart attack and kidney disease. Tolmetin sodium is used for its anti-inflammatory activity. Present therapy of Tolmetin sodium indicates the oral route of administration. Side effects of tolmetin sodium that have been recorded include gastrointestinal ulcers and hepatotoxicity. To overcome the side effects of tolmetin sodium, topical administration can be preferred over oral administration. Skin is a major barrier for topical dosage form. It aff.. Read More»
    DOI: 10.31858/0975-8453.14.1.41-46

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